| http://purl.uniprot.org/citations/35925388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35925388 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-ampullary small bowel adenocarcinoma is a rare neoplasm with an ominous prognosis, whose incidence is higher in some chronic immuno-inflammatory conditions, such as coeliac and Crohn's disease. Recently, claudin 18.2, a transmembrane protein normally expressed in gastric mucosa, has been recognized as a novel pan-cancer therapeutic target, and several clinical trials with claudin-18-directed drugs have shown promising results on various gastrointestinal malignancies. This is the first study focusing on claudin-18 expression in small bowel adenocarcinomas. The immunohistochemical expression of claudin-18 (clone 43-14A) was assessed in 81 small bowel adenocarcinomas of diverse aetiologies and correlated with several clinico-pathologic features and patient survival. We found that 28% of adenocarcinomas were immunoreactive for claudin-18, with cutoff values of ≥1% at any intensity, while 6% of cancers showed immunoexpression of ≥75% with 2+/3+ score. Moreover, claudin-18 (≥1%) was positively associated with cytokeratin 7 (CK7) and MUC5AC expression, showing CK7+/MUC5AC+ carcinomas the highest rate of positive cases, whereas a negative correlation was found between claudin-18 and CDX2 expression. In addition, some cancer-adjacent dysplastic growths and foci of gastric-type metaplasia in Crohn's disease-associated cases showed claudin-18 immunoreactivity. Survival analysis showed a non-significant trend towards a worse cancer-specific survival for claudin-18-positive cases. A fraction of small bowel adenocarcinomas, mainly sporadic or Crohn's disease-associated, and often exhibiting a non-intestinal immunoprofile, expressed claudin-18, suggesting that claudin-18-directed targeted therapy is worth investigating in such cancers."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00428-022-03393-6"xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Fassan M."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Lonardi S."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Guzzardo V."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Di Sabatino A."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Guerini C."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Paulli M."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Pedrazzoli P."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Vanoli A."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Grillo F."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Bergamo F."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Angerilli V."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Arpa G."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Lenti M.V."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/author | "Quaquarini E."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/name | "Virchows Arch"xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/pages | "853-863"xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/title | "Claudin-18 expression in small bowel adenocarcinoma: a clinico-pathologic study."xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://purl.uniprot.org/core/volume | "481"xsd:string |
| http://purl.uniprot.org/citations/35925388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35925388 |
| http://purl.uniprot.org/citations/35925388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35925388 |
| http://purl.uniprot.org/uniprot/#_P56856-mappedCitation-35925388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35925388 |