| http://purl.uniprot.org/citations/35929733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35929733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35929733 | http://www.w3.org/2000/01/rdf-schema#comment | "The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Whether appropriate levels of CED-1 are maintained for executing the engulfment function remains unknown. Here, we identified the C. elegans E3 ubiquitin ligase tripartite motif containing-21 (TRIM-21) as a component of the CED-1 pathway for apoptotic cell clearance. When the NPXY motif of CED-1 was bound to the adaptor protein CED-6 or the YXXL motif of CED-1 was phosphorylated by tyrosine kinase SRC-1 and subsequently bound to the adaptor protein NCK-1 containing the SH2 domain, TRIM-21 functioned in conjunction with UBC-21 to catalyze K48-linked poly-ubiquitination on CED-1, targeting it for proteasomal degradation. In the absence of TRIM-21, CED-1 accumulated post-translationally and drove cell corpse degradation defects, as evidenced by direct binding to VHA-10. These findings reveal a unique mechanism for the maintenance of appropriate levels of CED-1 to regulate apoptotic cell clearance."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.76436"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.76436"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Jing H."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Jing H."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/title | "trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/title | "trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35929733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35929733 |
| http://purl.uniprot.org/citations/35929733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35929733 |