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| http://purl.uniprot.org/citations/35944274 | http://www.w3.org/2000/01/rdf-schema#comment | "The increase of functional β-cell mass is paramount to maintaining glucose homeostasis in the setting of systemic insulin resistance and/or augmented metabolic load. Understanding compensatory mechanisms that allow β-cell mass adaptation may allow for the discovery of therapeutically actionable control nodes. In this study, we report the rapid and robust β-cell hyperplasic effect in a mouse model of overfeeding-induced obesity (OIO) based on direct gastric caloric infusion. By performing RNA sequencing in islets isolated from OIO mice, we identified Sin3a as a novel transcriptional regulator of β-cell mass adaptation. β-Cell-specific Sin3a knockout animals showed profound diabetes due to defective acquisition of postnatal β-cell mass. These findings reveal a novel regulatory pathway in β-cell proliferation and validate OIO as a model for discovery of other mechanistic determinants of β-cell adaptation."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.org/dc/terms/identifier | "doi:10.2337/db22-0306"xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/author | "Pajvani U.B."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/author | "Bartolome A."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/author | "Ravussin Y."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/author | "Ferrante A.W."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/pages | "2395-2401"xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/title | "An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak beta-Cell Mass Acquisition."xsd:string |
| http://purl.uniprot.org/citations/35944274 | http://purl.uniprot.org/core/volume | "71"xsd:string |
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