| http://purl.uniprot.org/citations/35963236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35963236 | http://www.w3.org/2000/01/rdf-schema#comment | "The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein acidic and rich in cysteine (SPARC), was inhibited by 2 years of 14% sustained CR in humans and elevated by obesity. SPARC converted anti-inflammatory macrophages into a pro-inflammatory phenotype with induction of interferon-stimulated gene (ISG) expression via the transcription factors IRF3/7. Mechanistically, SPARC-induced ISGs were dependent on toll-like receptor-4 (TLR4)-mediated TBK1, IRF3, IFN-β, and STAT1 signaling without engaging the Myd88 pathway. Metabolically, SPARC dampened mitochondrial respiration, and inhibition of glycolysis abrogated ISG induction by SPARC in macrophages. Furthermore, the N-terminal acidic domain of SPARC was required for ISG induction, while adipocyte-specific deletion of SPARC reduced inflammation and extended health span during aging. Collectively, SPARC, a CR-mimetic adipokine, is an immunometabolic checkpoint of inflammation and interferon response that may be targeted to delay age-related metabolic and functional decline."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2022.07.007"xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Wang A."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Ryu S."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Iwasaki A."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Artyomov M."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Ravussin E."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Dixit V.D."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/author | "Sidorov S."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/pages | "1609-1626.e7"xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/title | "The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging."xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/35963236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35963236 |
| http://purl.uniprot.org/citations/35963236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35963236 |
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