| http://purl.uniprot.org/citations/35969763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35969763 | http://www.w3.org/2000/01/rdf-schema#comment | "The metronome-like circadian regulation of sleep timing must still adapt to an uncertain environment. Recent studies in Drosophila indicate that neuromodulation not only plays a key role in clock neuron synchronization but also affects interactions between the clock network and brain sleep centers. We show here that the targets of neuromodulators, G Protein Coupled Receptors (GPCRs), are highly enriched in the fly brain circadian clock network. Single-cell sequencing indicates that they are not only enriched but also differentially expressed and contribute to clock neuron identity. We generated a comprehensive guide library to mutagenize individual GPCRs in specific neurons and verified the strategy by introducing a targeted sequencing approach. Combined with a behavioral screen, the mutagenesis strategy revealed a role of dopamine in sleep regulation by identifying two dopamine receptors and a clock neuron subpopulation that gate the timing of sleep."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2206066119"xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Rosbash M."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Xin J."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Herndon N."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Abruzzi K."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Schlichting M."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Richhariya S."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/author | "Lenh W."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/pages | "e2206066119"xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/title | "Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep."xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/35969763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35969763 |
| http://purl.uniprot.org/citations/35969763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35969763 |
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