| http://purl.uniprot.org/citations/35980806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35980806 | http://www.w3.org/2000/01/rdf-schema#comment | "Spermatogenesis is sustained by homeostatic balance between the self-renewal and differentiation of spermatogonial stem cells, which is dependent on the strict regulation of transcription factor and chromatin modulator gene expression. Chromodomain helicase DNA-binding protein 4 is highly expressed in spermatogonial stem cells but roles in mouse spermatogenesis are not fully understood. Here, we report that the germ-cell-specific deletion of chromodomain helicase DNA-binding protein 4 resulted in complete infertility in male mice, with rapid loss of spermatogonial stem cells and excessive germ cell apoptosis. Chromodomain helicase DNA-binding protein 4-knockdown in cultured spermatogonial stem cells also promoted the expression of apoptosis-related genes and thereby activated the tumor necrosis factor signaling pathway. Mechanistically, chromodomain helicase DNA-binding protein 4 occupies the genomic regulatory region of key apoptosis-related genes, including Jun and Nfkb1. Together, our findings reveal the determinant role of chromodomain helicase DNA-binding protein 4 in spermatogonial stem cells survival in vivo, which will offer insight into the pathogenesis of male sterility and potential novel therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.org/dc/terms/identifier | "doi:10.1093/biolre/ioac162"xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Jin C."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Zou D."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Miao S."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/author | "Mang X."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/pages | "1331-1344"xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/title | "CHD4 acts as a critical regulator in the survival of spermatogonial stem cells in mice†."xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/35980806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35980806 |
| http://purl.uniprot.org/citations/35980806 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35980806 |
| http://purl.uniprot.org/uniprot/#_E9QAS4-mappedCitation-35980806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35980806 |