| http://purl.uniprot.org/citations/35993548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35993548 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the DC mechanical sensor Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the reciprocal differentiation of TH1 and regulatory T (Treg) cells in cancer. Genetic deletion of Piezo1 in DCs inhibited the generation of TH1 cells while driving the development of Treg cells in promoting cancer growth in mice. Mechanistically, Piezo1-deficient DCs regulated the secretion of the polarizing cytokines TGFβ1 and IL-12, leading to increased TGFβR2-p-Smad3 activity and decreased IL-12Rβ2-p-STAT4 activity while inducing the reciprocal differentiation of Treg and TH1 cells. In addition, Piezo1 integrated the SIRT1-hypoxia-inducible factor-1 alpha (HIF1α)-dependent metabolic pathway and calcium-calcineurin-NFAT signaling pathway to orchestrate reciprocal TH1 and Treg lineage commitment through DC-derived IL-12 and TGFβ1. Our studies provide critical insight for understanding the role of the DC-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.79957"xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Bi Y."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Wang Y.'"xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/author | "Jia A."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/pages | "e79957"xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/title | "Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer."xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35993548 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35993548 |
| http://purl.uniprot.org/citations/35993548 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35993548 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-35993548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35993548 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-35993548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35993548 |
| http://purl.uniprot.org/uniprot/#_A7MCT8-mappedCitation-35993548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35993548 |
| http://purl.uniprot.org/uniprot/#_F6YAQ3-mappedCitation-35993548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35993548 |