| http://purl.uniprot.org/citations/3600768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3600768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3600768 | http://www.w3.org/2000/01/rdf-schema#comment | "The bacteriocidal capacity of phagocytic cells is impaired in X-linked chronic granulomatous disease (X-CGD), a disorder characterized by the absence of functional plasma-membrane-associated NADPH oxidase. The components of this oxidase system, their correspondence with specific genetic loci, and the primary protein defect in X-CGD remain incompletely defined. We recently reported cloning of the putative X-CGD gene on the basis of DNA linkage. To identify the predicted protein in vivo, antibodies were raised to a synthetic peptide derived from the complementary DNA sequence and to a fusion protein produced in Escherichia coli. In Western blots antisera detect a neutrophil protein of relative molecular mass in 90,000 (90K) that is absent in X-CGD patients. Antisera also react with the larger component of cytochrome b recently purified from neutrophil plasma membranes as a complex of glycosylated 90K and non-glycosylated 22K polypeptides. Based on our identification of the X-CGD protein in vivo, we propose that one of its critical roles is to interact with the 22K species to form a functional cytochrome b complex."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.org/dc/terms/identifier | "doi:10.1038/327717a0"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.org/dc/terms/identifier | "doi:10.1038/327717a0"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Parkos C.A."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Parkos C.A."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Brown R."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Brown R."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Dinauer M.C."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Dinauer M.C."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Jesaitis A.J."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/author | "Jesaitis A.J."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/pages | "717-720"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/pages | "717-720"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/title | "The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/title | "The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex."xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/volume | "327"xsd:string |
| http://purl.uniprot.org/citations/3600768 | http://purl.uniprot.org/core/volume | "327"xsd:string |