| http://purl.uniprot.org/citations/3600769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3600769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3600769 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic granulomatous disease (CGD) is a rare inherited disorder associated with a profound predisposition to infection due to the lack of a microbicidal oxidase system in the phagocytes of these patients. This syndrome is most commonly inherited through a defect on the X chromosome and the only clearly defined component of the oxidase system, the very unusual cytochrome b (b-245), has been shown to be missing from the cells of these patients. This cytochrome is a heterodimer composed of an alpha-chain of relative molecular mass (Mr) 23,000 (23K) and a 76-92K beta-chain; neither are detectable in neutrophils from X-linked CGD subjects. The defective X-CGD gene has recently been cloned by 'reverse genetics' but the protein predicted from the proposed complementary DNA sequence was not identified. We have purified the beta-chain of the cytochrome and sequenced 43 amino acids from the N terminus. Almost complete homology was obtained between this sequence and that of the complementary nucleotides 19-147 of the sequence of the X-CGD gene, originally designated as a non-coding region."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.org/dc/terms/identifier | "doi:10.1038/327720a0"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.org/dc/terms/identifier | "doi:10.1038/327720a0"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Totty N."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Totty N."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Teahan C."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Teahan C."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Segal A.W."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Segal A.W."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Parker P."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Parker P."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Rowe P."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/author | "Rowe P."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/pages | "720-721"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/pages | "720-721"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/title | "The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/title | "The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245."xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/volume | "327"xsd:string |
| http://purl.uniprot.org/citations/3600769 | http://purl.uniprot.org/core/volume | "327"xsd:string |