| http://purl.uniprot.org/citations/36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36008423 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue development and regeneration rely on the cooperation of multiple mesenchymal progenitor (MP) subpopulations. We recently identified Hic1 as a marker of quiescent MPs in multiple adult tissues. Here, we describe the embryonic origin of appendicular Hic1+ MPs and demonstrate that they arise in the hypaxial somite, and migrate into the developing limb at embryonic day 11.5, well after limb bud initiation. Time-resolved single-cell-omics analyses coupled with lineage tracing reveal that Hic1+ cells generate a unique MP hierarchy, that includes both recently identified adult universal fibroblast populations (Dpt+, Pi16+ and Dpt+ Col15a1+) and more specialised mesenchymal derivatives such as, peri and endoneurial cells, pericytes, bone marrow stromal cells, myotenocytes, tenocytes, fascia-resident fibroblasts, with limited contributions to chondrocytes and osteocytes within the skeletal elements. MPs endure within these compartments, continue to express Hic1 and represent a critical reservoir to support post-natal growth and regeneration."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-32695-1"xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/author | "Bose K."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/author | "Underhill T.M."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/author | "Scott R.W."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/author | "Arostegui M."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/pages | "4989"xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/title | "Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult."xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36008423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36008423 |
| http://purl.uniprot.org/citations/36008423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD9-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YV87-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVF3-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A387LAL0-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A2ALK0-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |
| http://purl.uniprot.org/uniprot/#_A0A387L9Y7-mappedCitation-36008423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36008423 |