| http://purl.uniprot.org/citations/36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36011315 | http://www.w3.org/2000/01/rdf-schema#comment | "Variants of the DEAD-Box Helicase 20 (DDX20), one of the microRNAs (miRNAs) machinery genes, can modulate miRNA/target gene expressions and, hence, influence cancer susceptibility and prognosis. Here, we aimed to unravel the association of DDX20 rs197412 T/C variant with colon cancer risk and/or prognosis in paired samples of 122 colon cancer and non-cancer tissue specimens by TaqMan allelic discrimination analysis. Structural/functional bioinformatic analyses were carried out, followed by a meta-analysis. We found that the T allele was more frequent in cancer tissues compared to control tissues (60.2% vs. 35.7%, p < 0.001). Furthermore, the T variant was highly frequent in primary tumors with evidence of recurrence (73% vs. 47.5%, p < 0.001). Genetic association models, adjusted by age and sex, revealed that the T allele was associated with a higher risk of developing colon cancer under heterozygote (T/C vs. C/C: OR = 2.35, 95%CI = 1.25−4.44, p < 0.001), homozygote (T/T vs. C/C: OR = 7.6, 95%CI = 3.5−16.8, p < 0.001), dominant (T/C-T/T vs. C/C: OR = 3.4, 95%CI = 1.87−8.5, p < 0.001), and recessive (T/T vs. C/C-T/C: OR = 4.42, 95%CI = 2.29−8.54, p = 0.001) models. Kaplan−Meier survival curves showed the shift in the C > T allele to be associated with poor disease-free survival. After adjusting covariates using a multivariate cox regression model, patients harboring C > T somatic mutation were 3.5 times more likely to develop a recurrence (p < 0.001). A meta-analysis of nine studies (including ours) showed a higher risk of CRC (81%) in subjects harboring the T/T genotype than in T/C + C/C genotypes, supporting the potential clinical utility of the specified study variant as a biomarker for risk stratification in CRC cases. However, results were not significant in non-colorectal cancers. In conclusion, the DDX20 rs197412 variant is associated with increased colon cancer risk and a higher likelihood of recurrence in the study population."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes13081404"xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Fawzy M.S."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Nemr N.A."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Toraih E.A."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Hobani Y.H."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Alelwani W."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Almars A.I."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Attallah S.M."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/author | "Shaalan A.A.M."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/pages | "1404"xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/title | "Genetic Variation in DEAD-Box Helicase 20 as a Putative Marker of Recurrence in Propensity-Matched Colon Cancer Patients."xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36011315 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36011315 |
| http://purl.uniprot.org/citations/36011315 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36011315 |
| http://purl.uniprot.org/uniprot/#_Q8IYV2-mappedCitation-36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/#_Q9H4N4-mappedCitation-36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/#_Q8TDR3-mappedCitation-36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/#_Q9UHI6-mappedCitation-36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/#_Q8NEH0-mappedCitation-36011315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/Q8NEH0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36011315 |
| http://purl.uniprot.org/uniprot/Q9H4N4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36011315 |