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http://purl.uniprot.org/citations/360214http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/360214http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/360214http://www.w3.org/2000/01/rdf-schema#comment"The pheA structural gene of the phenylalanine operon of Escherichia coli is preceded by a transcribed leader region of about 170 nucleotide pairs. In vitro transcription of plasmids and restriction fragments containing the phe promoter and leader region yields a major RNA transcript about 140 nucleotides in length. This transcript, pheA leader RNA, has the following features: (i) a potential ribosome binding site and AUG translation start codon about 20 nucleotides from its 5' end; (ii) 14 additional in phase amino acid codons and a UGA stop codon after the AUG; 7 of these 14 are Phe codons; (iii) a 3'-OH terminus about 140 nucleotides from the 5' end (transcription termination occurs in an A.T-rich region which is subsequent to a G.C-rich region; just beyond the site of transcription termination there is a sequence corresponding to a ribosome binding site and the AUG translation start codon of the pheA structural gene); (iv) a sequence which would permit extensive intrastrand stable hydrogen bonding. In addition to G.C-rich stem structures, highly analogous to those proposed for the leader RNAs of the tryptophan operons of E. coli and Salmonella typhimurium [Lee, F. & Yanofsky, C. (1977) Proc. Natl. Acad. Sci. USA 74, 4365-4369], there is also extensive base-pairing possible between the phe codon region and a more distal region of the leader transcript. The roles of synthesis of the Phe-rich leader peptide and secondary structure of the leader transcript in the regulation of transcription termination at the attenuator of the phe operon are discussed."xsd:string
http://purl.uniprot.org/citations/360214http://purl.org/dc/terms/identifier"doi:10.1073/pnas.75.9.4271"xsd:string
http://purl.uniprot.org/citations/360214http://purl.org/dc/terms/identifier"doi:10.1073/pnas.75.9.4271"xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Brown K."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Brown K."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Yanofsky C."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Yanofsky C."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Killingly D."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Killingly D."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Zurawski G.R."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/author"Zurawski G.R."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/date"1978"xsd:gYear
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/date"1978"xsd:gYear
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/pages"4271-4275"xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/pages"4271-4275"xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/title"Nucleotide sequence of the leader region of the phenylalanine operon of Escherichia coli."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/title"Nucleotide sequence of the leader region of the phenylalanine operon of Escherichia coli."xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/volume"75"xsd:string
http://purl.uniprot.org/citations/360214http://purl.uniprot.org/core/volume"75"xsd:string
http://purl.uniprot.org/citations/360214http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/360214
http://purl.uniprot.org/citations/360214http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/360214