| http://purl.uniprot.org/citations/36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36027915 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytotoxicity of tumor-specific T cells requires tumor cell-to-T cell contact-dependent induction of classic tumor cell apoptosis and pyroptosis. However, this may not trigger sufficient primary responses of solid tumors to adoptive cell therapy or prevent tumor antigen escape-mediated acquired resistance. Here we test myxoma virus (MYXV)-infected tumor-specific T (TMYXV) cells expressing chimeric antigen receptor (CAR) or T cell receptor (TCR), which systemically deliver MYXV into solid tumors to overcome primary resistance. In addition to T cell-induced apoptosis and pyroptosis, tumor eradication by CAR/TCR-TMYXV cells is also attributed to tumor cell autosis induction, a special type of cell death. Mechanistically, T cell-derived interferon γ (IFNγ)-protein kinase B (AKT) signaling synergizes with MYXV-induced M-T5-SKP-1-VPS34 signaling to trigger robust tumor cell autosis. CAR/TCR-TMYXV-elicited autosis functions as a type of potent bystander killing to restrain antigen escape. We uncover an unexpected synergy between T cells and MYXV to bolster solid tumor cell autosis that reinforces tumor clearance."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2022.08.001"xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Fang J."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "McFadden G."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Rahman M.M."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Jin G."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/author | "Xue G."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/pages | "973-985.e7"xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/title | "Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance."xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/36027915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36027915 |
| http://purl.uniprot.org/citations/36027915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36027915 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36027915 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36027915 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36027915 |
| http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36027915 |
| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-36027915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36027915 |