| http://purl.uniprot.org/citations/36030002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36030002 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD). Appending a p-N-pyrrolidinosulphonamide group to the arylamide group led to a 'first-in kind' inhibitor with IC50 = 228 nM. A co-crystal structure with STK 25 revealed productive interactions which were also reproduced using molecular docking. A new series of triazolo dihydro oxazine carboxamides of 3-t-butyl 5-aminopyrazole was not active against STK25."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2022.128950"xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Miallau L."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Nawrotek A."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Mirguet O."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Hanessian S."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Mautino G."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Kotschy A."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Hocine S."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Vuillard L.M."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Kiyeleko S."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/author | "Kuenemann M."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/pages | "128950"xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/title | "Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25."xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/36030002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36030002 |
| http://purl.uniprot.org/citations/36030002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36030002 |
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| http://purl.uniprot.org/uniprot/O00506 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36030002 |