| http://purl.uniprot.org/citations/36044856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36044856 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hippo tumor-suppressor pathway is frequently dysregulated in human cancers and represents a therapeutic target. However, strategies targeting the mammalian Hippo pathway are limited because of the lack of a well-established cell-surface regulator. Here, we show that transmembrane protein KIRREL1, by interacting with both SAV1 and LATS1/2, promotes LATS1/2 activation by MST1/2 (Hippo kinases), and LATS1/2 activation, in turn, inhibits activity of YAP/TAZ oncoproteins. Conversely, YAP/TAZ directly induce the expression of KIRREL1 in a TEAD1-4-dependent manner. Indeed, KIRREL1 expression positively correlates with canonical YAP/TAZ target gene expression in clinical tumor specimens and predicts poor prognosis. Moreover, transgenic expression of KIRREL1 effectively blocks tumorigenesis in a mouse intrahepatic cholangiocarcinoma model, indicating a tumor-suppressor role of KIRREL1. Hence, KIRREL1 constitutes a negative feedback mechanism regulating the Hippo pathway and serves as a cell-surface marker and potential drug target in cancers with YAP/TAZ dependency."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.111296"xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "He C."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Yu A."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Sha Z."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Zhong Z."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Lan F."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/author | "Yu F.X."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/pages | "111296"xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/title | "Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers."xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/36044856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36044856 |
| http://purl.uniprot.org/citations/36044856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36044856 |
| http://purl.uniprot.org/uniprot/#_B4DN67-mappedCitation-36044856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044856 |
| http://purl.uniprot.org/uniprot/#_B4E2Y3-mappedCitation-36044856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044856 |
| http://purl.uniprot.org/uniprot/#_P46937-mappedCitation-36044856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044856 |