| http://purl.uniprot.org/citations/36044864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36044864 | http://www.w3.org/2000/01/rdf-schema#comment | "Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism for seizure protection from fasting. We demonstrate that brain mTORC1 signaling is reduced after acute fasting of mice and that neuronal mTORC1 integrates GATOR1 complex-mediated amino acid and tuberous sclerosis complex (TSC)-mediated growth factor signaling. Neuronal mTORC1 is most sensitive to withdrawal of leucine, arginine, and glutamine, which are dependent on DEPDC5, a component of the GATOR1 complex. Metabolomic analysis reveals that Depdc5 neuronal-specific knockout mice are resistant to sensing significant fluctuations in brain amino acid levels after fasting. Depdc5 neuronal-specific knockout mice are resistant to the protective effects of fasting on seizures or seizure-induced death. These results establish that acute fasting reduces seizure susceptibility in a DEPDC5-dependent manner. Modulation of nutrients upstream of GATOR1 and mTORC1 could offer a rational therapeutic strategy for epilepsy treatment."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.111278"xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Sahin M."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Manning B.D."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Yuskaitis C.J."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Chandel N.S."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Chakrabarty R.P."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Mithal D.S."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Schrotter S."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Rossitto L.A."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Groff K.J."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Modasia J.B."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/author | "Morici C."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/pages | "111278"xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/title | "DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting."xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/36044864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36044864 |
| http://purl.uniprot.org/citations/36044864 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36044864 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YU49-mappedCitation-36044864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044864 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV31-mappedCitation-36044864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044864 |
| http://purl.uniprot.org/uniprot/#_P61460-mappedCitation-36044864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36044864 |