| http://purl.uniprot.org/citations/36056254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36056254 | http://www.w3.org/2000/01/rdf-schema#comment | "Polypeptide N-acetylgalactosamine transferase 3 (ppGalNAc-T3) is an enzyme involved in the initiation of O-GalNAc glycan biosynthesis. Acting as a writer of frequent post-translational modification (PTM) on human proteins, ppGalNAc-T3 has key functions in the homeostasis of human cells and tissues. We review the relevant roles of this molecule in the biosynthesis of O-GalNAc glycans, as well as in biological functions related to human physiological and pathological conditions. With main emphasis in ppGalNAc-T3, we draw attention to the different ways involved in the modulation of ppGalNAc-Ts enzymatic activity. In addition, we take notice on recent reports of ppGalNAc-T3 having different subcellular localizations, highlight critical intrinsic and extrinsic functions in cellular physiology that are exerted by ppGalNAc-T3-synthesized PTMs, and provide an update on several human pathologies associated with dysfunctional ppGalNAc-T3. Finally, we propose biotechnological tools as new therapeutic options for the treatment of pathologies related to altered ppGalNAc-T3. KEY MESSAGES: ppGalNAc-T3 is a key enzyme in the human O-GalNAc glycans biosynthesis. enzyme activity is regulated by PTMs, lectin domain and protein-protein interactions. ppGalNAc-T3 is located in human Golgi apparatus and cell nucleus. ppGalNAc-T3 has a central role in cell physiology as well as in several pathologies. Biotechnological tools for pathological management are proposed."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00109-022-02249-5"xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Irazoqui F.J."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Angeloni G."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Lardone R.D."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Garcia V.A."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Lorenz V."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Sendra V.G."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Zlocowski N."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Parodi P."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Cejas R.B."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Ferrero F.A."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/author | "Garay Y.C."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/name | "J Mol Med (Berl)"xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/pages | "1387-1403"xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/title | "Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health."xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/36056254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36056254 |
| http://purl.uniprot.org/citations/36056254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36056254 |
| http://purl.uniprot.org/uniprot/#_B2R8J0-mappedCitation-36056254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36056254 |
| http://purl.uniprot.org/uniprot/#_Q14435-mappedCitation-36056254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36056254 |
| http://purl.uniprot.org/uniprot/#_Q68VJ6-mappedCitation-36056254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36056254 |
| http://purl.uniprot.org/uniprot/Q14435 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36056254 |