| http://purl.uniprot.org/citations/36056285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36056285 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have suggested that circular RNAs (circRNAs) play important regulatory roles in cancer progression. Previous evidence exhibited the aberrant upregulation of circ_0061140 in ovarian cancer. However, the detailed role of circ_0061140 in ovarian cancer progression and its associated mechanism remain largely unknown and need further exploration. The expression of circ_0061140, microRNA-761 (miR-761) and leucine zipper and EF-hand containing transmembrane protein 1 (LETM1) was checked by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) or western blot. Cell Counting Kit-8 (CCK8), colony formation, 5-Ethynyl-2'-deoxyuridine (EdU), flow cytometry, wound healing, transwell, and tube formation assays were conducted to assess cell functions. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were performed to confirm the interaction between miR-761 and circ_0061140 or LETM1. Xenograft tumor model was established to analyze the role of circ_0061140 in tumor growth in vivo. Circ_0061140 expression was notably up-regulated in ovarian cancer tissues and cell lines. Circ_0061140 knockdown suppressed the proliferation, migration, invasion, and angiogenesis and triggered the apoptosis of ovarian cancer cells. Circ_0061140 directly interacted with miR-761, and circ_0061140 silencing-mediated anti-tumor effects were partly abolished by miR-761 knockdown in ovarian cancer cells. LETM1 was a direct target of miR-761, and LETM1 overexpression partly counteracted miR-761-induced anti-tumor effects. Circ_0061140 could up-regulate LETM1 expression by sponging miR-761. Circ_0061140 knockdown significantly suppressed xenograft tumor growth in vivo. Circ_0061140 aggravated ovarian cancer progression through miR-761-dependent regulation of LETM1."xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10528-022-10277-6"xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/name | "Biochem Genet"xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/pages | "628-650"xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/title | "Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling."xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/36056285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36056285 |
| http://purl.uniprot.org/citations/36056285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36056285 |
| http://purl.uniprot.org/uniprot/#_O95202-mappedCitation-36056285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36056285 |
| http://purl.uniprot.org/uniprot/O95202 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36056285 |