| http://purl.uniprot.org/citations/36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36065769 | http://www.w3.org/2000/01/rdf-schema#comment | "Nesfatin-1, a newly discovered adipokine derived from nucleobindin-2 (NUCB2), has been described as a new prognostic marker in cancers. This study aimed to explore the functional role of NUCB2/nesfatin-1 in the cell proliferation, migration and invasion in gastric carcinoma (GC). The expressions of NUCB2/nesfatin-1 in GC tissues and normal adjacent tissues (NATs) were compared, and the effect of inhibition of NUCB2/nesfatin-1 on the cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in GC cell line SGC-7901 was investigated. Cell transfection was conducted to inhibit NUCB2/nesfatin-1 by short hairpin RNA. Cell proliferation, migration and invasion abilities were determined using cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), wound healing and transwell assays, respectively. The expressions of EMT markers E-Cadherin and N-Cadherin were determined using western blotting. The expression of NUCB2/nesfatin-1 protein in GC tissues was significantly increased compared with that in NATs. Consistently, the serum concentrations of NUCB2/nesfatin-1 were significantly higher in patients with GC as compared with those in the control group. Moreover, the results of CCK-8 assay and EdU assay indicated that knockdown of NUCB2/nesfatin-1 could markedly decrease SGC-7901 proliferation. Furthermore, the results of wound healing assay and transwell assay demonstrated that knockdown of NUCB2/nesfatin-1 significantly suppressed SGC-7901 migration and invasion abilities. Additionally, knockdown of NUCB2/nesfatin-1 decreased the expressions of N-Cadherin and increased the expressions of E-Cadherin in SGC-7901 cells. These findings suggest that knockdown of NUCB2/nesfatin-1 suppressed the proliferation, migration, invasion and EMT of SGC-7901 cells, suggesting a potentially promising therapeutic target for GC."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.17522"xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Ren L."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Shi Z."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/author | "Bao D."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/pages | "4986-4994"xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/title | "Nucleobindin-2/nesfatin-1 enhances the cell proliferation, migration, invasion and epithelial-mesenchymal transition in gastric carcinoma."xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/36065769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36065769 |
| http://purl.uniprot.org/citations/36065769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36065769 |
| http://purl.uniprot.org/uniprot/#_A0A097EV82-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/#_A7LNF3-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/#_A7LNF4-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/#_A7LNF5-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/#_P80303-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/#_Q2L696-mappedCitation-36065769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/A7LNF4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/Q2L696 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36065769 |
| http://purl.uniprot.org/uniprot/P80303 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36065769 |