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http://purl.uniprot.org/citations/36076647http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36076647http://www.w3.org/2000/01/rdf-schema#comment"

Background

Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder, mainly characterized by severe optic neuritis, transverse myelitis and the high levels of antibodies against NMO-immunoglobulin G (IgG) or aquaporin-4 (AQP4). HLA-DR and HLA-DQ alleles within the HLA class II region on chromosome 6p21 are known to play a significant role in several autoimmune diseases including NMO. The rationale of the current case-control study is to explore the association of HLA-DRB1 and HLA-DQB1 alleles with the risk of NMO and its association with the clinical and serological markers.

Methods

A total of 158 samples (38 NMO cases and 120-age and ethnicity matched controls) were genotyped for the HLA-DRB1 and HLA-DQB1 alleles by using PCR-SSP method.

Results

Our analysis showed significant association of HLA-DRB1*10 allele (OR 2.63, 95% CI: 1.18-5.83, p=0.02) with NMO whereas DRB1*14 showed protective role against NMO (OR 0.33: 95% CI: 0.11-0.94, p=0.043). HLA-DRB1*10 allele also showed significant association in patients with NMO-IgG positive antibody (OR 3.28: 95% CI: 1.42-7.5, p=0.006). There was no association of HLA DQB1 alleles with NMO and also with NMO-IgG antibody. Among the haplotypes groups, HLA-DRB1*10-DQB1*05 (OR 2.61, 95% CI: 1.11-6.1, p=0.03), HLA-DRB1*15-DQB1*03 (OR 4.5, 95% CI: 1.81-11.5, p=0.001) were strongly associated with the risk of NMO, whereas DRB1*14-DQB1*05 (OR 0.20, 95% CI: 0.060-0.721, p=0.008) showed negative association with NMO.

Conclusion

From this study, it is concluded that the HLA-DRB1*10 and DRB1*10-DQB1*05 and HLA-DRB1*15-DQB1*03 haplotypes may influence the susceptibility to NMO among the South Indians. Additionally we found DRB1*14 allele and DRB1*14-DQB1*05 haplotype showed protective role for NMO."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.org/dc/terms/identifier"doi:10.4103/0028-3886.355130"xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Kutala V.K."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Katkam S.K."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Kanikannan M.A."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Kathgave R."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Kumaraswamy K."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/author"Yareeda S."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/name"Neurol India"xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/pages"1481-1486"xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/title"Association of HLA DRB1-DQB1 Haplotypes with the Risk for Neuromyelitis Optica among South Indians."xsd:string
http://purl.uniprot.org/citations/36076647http://purl.uniprot.org/core/volume"70"xsd:string
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