| http://purl.uniprot.org/citations/36077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36077184 | http://www.w3.org/2000/01/rdf-schema#comment | "Phospholipid scramblase 4 (PLSCR4) is a member of a conserved enzyme family with high relevance for the remodeling of phospholipid distribution in the plasma membrane and the regulation of cellular signaling. While PLSCR1 and -3 are involved in the regulation of adipose-tissue expansion, the role of PLSCR4 is so far unknown. PLSCR4 is significantly downregulated in an adipose-progenitor-cell model of deficiency for phosphatase and tensin homolog (PTEN). PTEN acts as a tumor suppressor and antagonist of the growth and survival signaling phosphoinositide 3-kinase (PI3K)/AKT cascade by dephosphorylating phosphatidylinositol-3,4,5-trisphosphate (PIP3). Patients with PTEN germline deletion frequently develop lipomas. The underlying mechanism for this aberrant adipose-tissue growth is incompletely understood. PLSCR4 is most highly expressed in human adipose tissue, compared with other phospholipid scramblases, suggesting a specific role of PLSCR4 in adipose-tissue biology. In cell and mouse models of lipid accumulation, we found PLSCR4 to be downregulated. We observed increased adipogenesis in PLSCR4-knockdown adipose progenitor cells, while PLSCR4 overexpression attenuated lipid accumulation. PLSCR4 knockdown was associated with increased PIP3 levels and the activation of AKT. Our results indicated that PLSCR4 is a regulator of PI3K/AKT signaling and adipogenesis and may play a role in PTEN-associated adipose-tissue overgrowth and lipoma formation."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms23179787"xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Kehr S."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Le Duc D."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Kalwa H."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Kiess W."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Garten A."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Barth L.A.G."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Kirstein A.S."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Nebe M."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Velluva A."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Kolbig F."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/author | "Prabutzki P."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/pages | "9787"xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/title | "Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation."xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/36077184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36077184 |
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| http://purl.uniprot.org/uniprot/#_A0A142IKA9-mappedCitation-36077184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36077184 |