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http://purl.uniprot.org/citations/36107737http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36107737http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36107737http://www.w3.org/2000/01/rdf-schema#comment"Neuropeptides are signaling molecules that regulate almost all physiological processes in animals. Around 50 different genes for neuropeptides have been described in insects. In Coleoptera, which is the largest insect order based on numbers of described species, knowledge about neuropeptides and protein hormones is still limited to a few species. Here, we analyze the neuropeptidomes of two closely related tenebrionid beetles: Tenebrio molitor and Zophobas atratus─both of which are model species in physiological and pharmacological research. We combined transcriptomic and mass spectrometry analyses of the central nervous system to identify neuropeptides and neuropeptide-like and protein hormones. Several precursors were identified in T. molitor and Z. atratus, of which 50 and 40, respectively, were confirmed by mass spectrometry. This study provides the basis for further functional studies of neuropeptides as well as for the design of environmentally friendly and species-specific peptidomimetics to be used as biopesticides. Furthermore, since T. molitor has become accepted by the European Food Safety Authority as a novel food, a deeper knowledge of the neuropeptidome of this species will prove useful for optimizing production programs at an industrial scale."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.org/dc/terms/identifier"doi:10.1021/acs.jproteome.1c00694"xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Ragionieri L."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Ragionieri L."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Marciniak P."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Marciniak P."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Pacholska-Bogalska J."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/author"Pacholska-Bogalska J."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/name"J. Proteome Res."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/name"J Proteome Res"xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/pages"2247-2260"xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/title"Neuropeptidomes of Tenebrio molitor L. and Zophobas atratus Fab. (Coleoptera, Polyphaga: Tenebrionidae)."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/title"Neuropeptidomes of Tenebrio molitor L. and Zophobas atratus Fab. (Coleoptera, Polyphaga: Tenebrionidae)."xsd:string
http://purl.uniprot.org/citations/36107737http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/36107737http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36107737
http://purl.uniprot.org/citations/36107737http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36107737
http://purl.uniprot.org/citations/36107737http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36107737
http://purl.uniprot.org/citations/36107737http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36107737
http://purl.uniprot.org/uniprot/A0A977SRG4http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/36107737
http://purl.uniprot.org/uniprot/A0A977SQY6http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/36107737
http://purl.uniprot.org/uniprot/A0A977SQ05http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/36107737