| http://purl.uniprot.org/citations/36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36140736 | http://www.w3.org/2000/01/rdf-schema#comment | "Ulcerative colitis (UC) results from a complex interplay between the environment, gut microbiota, host genetics, and immunity. Runt-related transcription factor 3 (RUNX3) regulates Th1/Th2 balance and, thus, the synthesis of cytokines and inflammation. We aimed to analyze the dependence of RUNX3 promoter 2 (P2) methylation level on: age, sex, body mass index (BMI), C-reactive protein (CRP), serum albumin, disease duration, Pediatric Ulcerative Colitis Activity Index (PUCAI), the Paris classification, and exposure to medications. This multicenter, cross-sectional study recruited hospitalized children with UC. Methylation of RUNX3 P2 was measured with methylation-sensitive restriction enzymes in the whole blood DNA. Sixty-four children were enrolled, with a mean age of 14.5 ± 2.8 years. Half of them were female (51.6%), and the average BMI Z-score was -0.44 ± 1.14. The mean methylation of RUNX3 P2 was 54.1 ± 13.3%. The methylation level of RUNX3 P2 did not correlate with age, sex, nutritional status, CRP, albumin, PUCAI, or the extent of colitis (Paris E1-E4). RUNX3 P2 methylation did not differ between patients recruited within two and a half months of diagnosis and children who had UC for at least a year. Current or past exposure to biologics, immunosuppressants, or steroids was not associated with RUNX3 P2 methylation. Methylation of RUNX3 promoter 2 in whole blood DNA does not seem to be associated with the characteristics of UC in children."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes13091568"xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Nowak J.K."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Walkowiak J."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Grzybowska-Chlebowczyk U."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Szaflarska-Poplawska A."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Kwiecien J."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Kierkus J."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Banaszkiewicz A."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/author | "Dybska E."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/pages | "1568"xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/title | "Methylation of RUNX3 Promoter 2 in the Whole Blood of Children with Ulcerative Colitis."xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36140736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36140736 |
| http://purl.uniprot.org/citations/36140736 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36140736 |
| http://purl.uniprot.org/uniprot/#_B4DVE5-mappedCitation-36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/#_B4DT53-mappedCitation-36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/#_Q9Y3R8-mappedCitation-36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/#_O14814-mappedCitation-36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/#_Q13761-mappedCitation-36140736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/B4DT53 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36140736 |
| http://purl.uniprot.org/uniprot/B4DVE5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36140736 |