| http://purl.uniprot.org/citations/36149942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36149942 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular programs involved in regulatory T (Treg) cell activation and homeostasis remain incompletely understood. Here, we show that T cell receptor (TCR) signaling in Treg cells induces the nuclear translocation of serine/threonine kinase 4 (Stk4), leading to the formation of an Stk4-NF-κB p65-Foxp3 complex that regulates Foxp3- and p65-dependent transcriptional programs. This complex was stabilized by Stk4-dependent phosphorylation of Foxp3 on serine-418. Stk4 deficiency in Treg cells, either alone or in combination with its homolog Stk3, precipitated a fatal autoimmune lymphoproliferative disease in mice characterized by decreased Treg cell p65 expression and nuclear translocation, impaired NF-κB p65-Foxp3 complex formation, and defective Treg cell activation. In an adoptive immunotherapy model, overexpression of p65 or the phosphomimetic Foxp3S418E in Stk3/4-deficient Treg cells ameliorated their immune regulatory defects. Our studies identify Stk4 as an essential TCR-responsive regulator of p65-Foxp3-dependent transcription that promotes Treg cell-mediated immune tolerance."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciimmunol.abl8357"xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Mehta S."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Cui Y."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Keles S."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Fong J."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Angelini C."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Chatila T.A."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Schmitz-Abe K."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Baris S."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Kiykim A."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Charbonnier L.M."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Benamar M."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Eklioglu B.S."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Stephen-Victor E."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Jugder B.E."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Fatou B."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Buyanbat A."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Karabiber E."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/author | "Poondi-Krishnan V."xsd:string |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36149942 | http://purl.uniprot.org/core/name | "Sci Immunol"xsd:string |