| http://purl.uniprot.org/citations/36154948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36154948 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The mechanisms underlying tissue-specific phenotypes are not understood. Complex I (cI) is classically considered the entry point for electrons into the ETC, and in vitro experiments indicate that cI is required for basal respiration and maintenance of the NAD+/NADH ratio, an indicator of cellular redox status. This finding has largely not been tested in vivo. Here, we report that mitochondrial complex I is dispensable for homeostasis of the adult mouse liver; animals with hepatocyte-specific loss of cI function display no overt phenotypes or signs of liver damage, and maintain liver function, redox and oxygen status. Further analysis of cI-deficient livers did not reveal significant proteomic or metabolic changes, indicating little to no compensation is required in the setting of complex I loss. In contrast, complex IV (cIV) dysfunction in adult hepatocytes results in decreased liver function, impaired oxygen handling, steatosis, and liver damage, accompanied by significant metabolomic and proteomic perturbations. Our results support a model whereby complex I loss is tolerated in the mouse liver because hepatocytes use alternative electron donors to fuel the mitochondrial ETC."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.80919"xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Mishra P."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "DeBerardinis R.J."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Frank A."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "McFadden D.G."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Wansapura J."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Lemoff A."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "House S."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Shelton S.D."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Lesner N.P."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/author | "Menezes C.J."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/pages | "e80919"xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/title | "Differential requirements for mitochondrial electron transport chain components in the adult murine liver."xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/36154948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36154948 |
| http://purl.uniprot.org/citations/36154948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36154948 |
| http://purl.uniprot.org/uniprot/#_A0A0R3P9C8-mappedCitation-36154948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36154948 |
| http://purl.uniprot.org/uniprot/#_Q3UDN4-mappedCitation-36154948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36154948 |
| http://purl.uniprot.org/uniprot/#_Q3TAS4-mappedCitation-36154948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36154948 |