| http://purl.uniprot.org/citations/36159793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36159793 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or their receptors, fewer Treg apparently develop in the thymus. However, it was recently shown that a substantial part of thymic Treg are cells that had recirculated from the periphery back to the thymus, troubling interpretation of these results. We therefore reassessed the involvement of IL-2 and IL-15 in the development of Treg, taking into account Treg-recirculation. At the age of three weeks, when in wt and IL-15-deficient (but not in IL-2-deficient) mice substantial amounts of recirculating Treg are present in the thymus, we found similarly reduced proportions of newly developed Treg in absence of IL-2 or IL-15, and in absence of both cytokines even less Treg developed. In neonates, when practically no recirculating Treg were found in the thymus, the absence of IL-2 led to substantially more reduced Treg-development than deficiency in IL-15. IL-2 but not IL-15 modulated the CD25, GITR, OX40, and CD73-phenotypes of the thymus-egress-competent and periphery-seeding Treg-population. Interestingly, IL-2 and IL-15 also modulated the TCR-repertoire expressed by developing Treg. Upon transfer into Treg-less Foxp3sf mice, newly developed Treg from IL-2-(and to a much lesser extent IL-15-) deficient mice suppressed immunopathology less efficiently than wt Treg. Taken together, our results firmly establish important non-redundant quantitative and qualitative roles for IL-2 and, to a lesser extent, IL-15 in intrathymic Treg-development."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2022.965303"xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Joffre O.P."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Galindo-Albarran A.O."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Hollander G."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Detraves C."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Romagnoli P."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Apert C."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Zuklys S."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Fillatreau S."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "van Meerwijk J.P.M."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Santamaria J.C."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Castan S."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Haegeman B."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "McJannett N."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/author | "Michaud H."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/pages | "965303"xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/title | "IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36159793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36159793 |
| http://purl.uniprot.org/citations/36159793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36159793 |