| http://purl.uniprot.org/citations/36175183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36175183 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma worldwide, accounting for about 40% of cases. The role of cytokines in the pathogenesis of lymphomas has been rarely addressed, although cytokines have a close immunological relationship with lymphocytes. We observed overexpression of interleukin (IL)-20 in reactive germinal centres (GCs) leading us to hypothesise that IL-20 may play a role in lymphomagenesis. In this study, we surveyed for IL-20 expression in various types of lymphoma and found that IL-20 was expressed most frequently in follicular lymphoma (94%), but also in Burkitt lymphoma (81%), mantle cell lymphoma (57%), nodal marginal zone lymphoma (56%), Hodgkin lymphomas (50%), small lymphocytic lymphoma (50%) and diffuse large B-cell lymphoma (DLBCL, 48%). IL-20 was not expressed in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), lymphoplasmacytic lymphoma, and plasmacytoma. T-cell lymphomas were largely negative for IL-20 expression, except for anaplastic large cell lymphoma (ALCL, 61%), which frequently expressed IL-20, especially in cutaneous ALCL, and showed an inverse association with ALK expression (p=0.024). We further tested IL-20 expression in another large cohort of DLBCL and found IL-20 expression more frequently in germinal centre B-cell (GCB) than in non-GCB subtype [16/26 (62%) versus 24/64 (38%), p=0.038]. In this cohort, IL-20 was associated with a lower rate of extranodal involvement (p=0.009), bone marrow involvement (p=0.040), and better overall survival (p=0.020). Mechanistically, IL-20 overexpression promoted G1 cell cycle arrest and subsequent apoptosis of DLBCL cells and vice versa in vitro. We conclude that IL-20 may be involved in lymphomagenesis and may be useful as a prognostic marker in patients with DLBCL. In addition, IL-20 plays an inhibitory role in DLBCL growth, probably through cell cycle regulation."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pathol.2022.07.007"xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Huang Y.C."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Yang S.J."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Chen T.Y."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Chang K.C."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Chen Y.P."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Chang M.S."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Chiang P.M."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Medeiros L.J."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Hung L.Y."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/author | "Lu Y.S."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/name | "Pathology"xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/pages | "94-103"xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/title | "Overexpression of interleukin-20 correlates with favourable prognosis in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/36175183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36175183 |
| http://purl.uniprot.org/citations/36175183 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36175183 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C4W0-mappedCitation-36175183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36175183 |
| http://purl.uniprot.org/uniprot/#_Q9NYY1-mappedCitation-36175183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36175183 |
| http://purl.uniprot.org/uniprot/A0A7R8C4W0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36175183 |
| http://purl.uniprot.org/uniprot/Q9NYY1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36175183 |