| http://purl.uniprot.org/citations/36180527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36180527 | http://www.w3.org/2000/01/rdf-schema#comment | "SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated with cardiovascular complications including long-term outcomes. The presence of virus in cardiac tissue of patients with COVID-19 suggests this is a direct, rather than secondary, effect of infection. Here, by expressing individual SARS-CoV-2 proteins in the Drosophila heart, we demonstrate interaction of virus Nsp6 with host proteins of the MGA/MAX complex (MGA, PCGF6 and TFDP1). Complementing transcriptomic data from the fly heart reveal that this interaction blocks the antagonistic MGA/MAX complex, which shifts the balance towards MYC/MAX and activates glycolysis-with similar findings in mouse cardiomyocytes. Further, the Nsp6-induced glycolysis disrupts cardiac mitochondrial function, known to increase reactive oxygen species (ROS) in heart failure; this could explain COVID-19-associated cardiac pathology. Inhibiting the glycolysis pathway by 2-deoxy-D-glucose (2DG) treatment attenuates the Nsp6-induced cardiac phenotype in flies and mice. These findings point to glycolysis as a potential pharmacological target for treating COVID-19-associated heart failure."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-022-03986-6"xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Zhu J.Y."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Han Z."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Lee J.G."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Kane M.A."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "van de Leemput J."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/author | "Yang P.'"xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/pages | "1039"xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/title | "SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis."xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/36180527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36180527 |
| http://purl.uniprot.org/citations/36180527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36180527 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHC8-mappedCitation-36180527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36180527 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFI7-mappedCitation-36180527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36180527 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEL0-mappedCitation-36180527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36180527 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF99-mappedCitation-36180527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36180527 |