http://purl.uniprot.org/citations/36181281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/36181281 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCircular RNAs (circRNAs) have been implicated in the initiation and development of various cancers. This study explored the potential contribution of hsa_hsa_circ_0081069 in the progression of colorectal cancer (CRC).MethodsThe gene expression was analyzed by qRT-PCR. Functional roles of hsa_circ_0081069 were examined by shRNA-mediated silencing using CCK-8 proliferation assay, Transwell migration and invasion assay, tube formation assay. The tumorigenesis and metastasis of CRC cells were assess in a xenograft mouse model.ResultsHsa_circ_0081069 was significantly upregulated in CRC tissues and cells. Hsa_circ_0081069 knockdown suppressed the proliferation, migration and invasion in CRC cells, as well as the angiogenesis. Silencing hsa_circ_0081069 also impaired the tumorigenesis of CRC cells in a xenograft mouse model. Furthermore, miR-665 was identified as an interacting partner of hsa_circ_0081069, which was negatively regulated by hsa_circ_0081069. miR-665 targeted the mRNA of E2F3 to suppress its expression. We further demonsatred that miR-665/E2F3 axis mediated the functional role of hsa_circ_0081069 in regulating the malignant phenotype of CRC cells.ConclusionsCollectively, our study suggests that hsa_circ_0081069 could serve as a prognostic marker in progression of CRC. Targeting hsa_circ_0081069 and miR-665/E2F3 axis could serve as potential therapeutic strategies for CRC treatment."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcla.24710"xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/author | "Xie J."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/author | "Jin D."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/name | "J Clin Lab Anal"xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/pages | "e24710"xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/title | "Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR-665 and regulating E2F3 expression."xsd:string |
http://purl.uniprot.org/citations/36181281 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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