| http://purl.uniprot.org/citations/36191189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36191189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36191189 | http://www.w3.org/2000/01/rdf-schema#comment | "The cilium-centrosome complex contains triplet, doublet, and singlet microtubules. The lumenal surfaces of each microtubule within this diverse array are decorated by microtubule inner proteins (MIPs). Here, we used single-particle cryo-electron microscopy methods to build atomic models of two types of human ciliary microtubule: the doublet microtubules of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated human spermatozoa. We discover that SPACA9 is a polyspecific MIP capable of binding both microtubule types. SPACA9 forms intralumenal striations in the B tubule of respiratory doublet microtubules and noncontinuous spirals in sperm singlet microtubules. By acquiring new and reanalyzing previous cryo-electron tomography data, we show that SPACA9-like intralumenal striations are common features of different microtubule types in animal cilia. Our structures provide detailed references to help rationalize ciliopathy-causing mutations and position cryo-EM as a tool for the analysis of samples obtained directly from ciliopathy patients."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2207605119"xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2207605119"xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Gui M."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Gui M."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Kollman J.M."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Kollman J.M."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Acharya V."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Acharya V."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Burgoyne T."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Burgoyne T."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Croft J.T."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Croft J.T."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Hoog J.L."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Hoog J.L."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Zabeo D."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/author | "Zabeo D."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/36191189 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |