| http://purl.uniprot.org/citations/36191209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36191209 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) play an essential role in plant growth and development, and as such, their biogenesis is fine-tuned via regulation of the core microprocessor components. Here, we report that Arabidopsis AAR2, a homolog of a U5 snRNP assembly factor in yeast and humans, not only acts in splicing but also promotes miRNA biogenesis. AAR2 interacts with the microprocessor component hyponastic leaves 1 (HYL1) in the cytoplasm, nucleus, and dicing bodies. In aar2 mutants, abundance of nonphosphorylated HYL1, the active form of HYL1, and the number of HYL1-labeled dicing bodies are reduced. Primary miRNA (pri-miRNA) accumulation is compromised despite normal promoter activities of MIR genes in aar2 mutants. RNA decay assays show that the aar2-1 mutation leads to faster degradation of pri-miRNAs in a HYL1-dependent manner, which reveals a previously unknown and negative role of HYL1 in miRNA biogenesis. Taken together, our findings reveal a dual role of AAR2 in miRNA biogenesis and pre-messenger RNA splicing."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2208415119"xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Le B."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "You C."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Manavella P.A."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Flynn N."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/author | "Achkar N."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/pages | "e2208415119"xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/title | "Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis."xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/36191209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36191209 |
| http://purl.uniprot.org/citations/36191209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36191209 |
| http://purl.uniprot.org/uniprot/#_A0A654ELX0-mappedCitation-36191209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36191209 |
| http://purl.uniprot.org/uniprot/#_A0A1P8AQD8-mappedCitation-36191209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36191209 |
| http://purl.uniprot.org/uniprot/#_F4IEV7-mappedCitation-36191209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36191209 |
| http://purl.uniprot.org/uniprot/#_O04492-mappedCitation-36191209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36191209 |