| http://purl.uniprot.org/citations/36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36196585 | http://www.w3.org/2000/01/rdf-schema#comment | "The dentate gyrus, a gateway for input to the hippocampal formation, arises from progenitors in the medial telencephalic neuroepithelium adjacent to the cortical hem. Dentate progenitors navigate a complex migratory path guided by two cell populations that arise from the hem, the fimbrial glia and Cajal-Retzius (CR) cells. As the hem expresses multiple Wnt genes, we examined whether β-catenin, which mediates canonical Wnt signaling and also participates in cell adhesion, is necessary for the development of hem-derived lineages. We report that, in mice, the fimbrial glial scaffold is disorganized and CR cells are mispositioned upon hem-specific disruption of β-catenin. Consequently, the dentate migratory stream is severely affected, and the dentate gyrus fails to form. Using selective Cre drivers, we further determined that β-catenin function is required in the fimbrial glial scaffold, but not in the CR cells, for guiding the dentate migration. Our findings highlight a primary requirement for β-catenin for the organization of the fimbrial scaffold and a secondary role for this factor in dentate gyrus morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.200953"xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Holtzman M.J."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Chatterjee M."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Datta D."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Suresh V."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Tole S."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/author | "Parichha A."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/pages | "dev200953"xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/title | "Dentate gyrus morphogenesis is regulated by beta-catenin function in hem-derived fimbrial glia."xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/36196585 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36196585 |
| http://purl.uniprot.org/citations/36196585 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36196585 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVT2-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
| http://purl.uniprot.org/uniprot/#_E9Q990-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
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| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
| http://purl.uniprot.org/uniprot/#_D3YWT3-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |
| http://purl.uniprot.org/uniprot/#_D3Z1L0-mappedCitation-36196585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36196585 |