| http://purl.uniprot.org/citations/36205702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36205702 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the most important chemotherapeutics for non-small-cell lung cancer (NSCLC) therapy. The resistance to EGFR-TKIs is one of the biggest obstacles to NSCLC outcome. In this study, taking advantage of phospho- and proximal proteomic techniques, we analyzed the network rearrangement in cell lines responding to AZD9291 treatment and found that cell-cell adhesion was dramatically enhanced in AZD9291-resistant cells. Further analysis revealed that protein tyrosine kinase 7 (PTK7) expression was significantly elevated. Knockdown or overexpression assays showed that PTK7 played a critical role in improving cell adhesion, which enhanced drug resistance. Because PTK7 is a membrane-localized pseudokinase, the proximal labeling probe BirA* was fused to reveal PTK7-interacting proteins. We found that PTK7 interacted with and stabilized NDRG1, which is located predominantly adjacent to adherens junctions. Downregulation of PTK7 or NDRG1 eliminated the resistance of H1975-resistant (H1975-R) and PC9-resistant (PC9-R) cells to AZD9291, suggesting that the PTK7-NDRG1 axis might be a potential target to eliminate the EGFR-TKI resistance during NSCLC therapy."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.org/dc/terms/identifier | "doi:10.1021/acschembio.2c00479"xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Hou Z."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Su T."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Meng C."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/author | "Lei P."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/name | "ACS Chem Biol"xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/pages | "2849-2862"xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/title | "Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291."xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/36205702 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36205702 |
| http://purl.uniprot.org/citations/36205702 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36205702 |
| http://purl.uniprot.org/uniprot/#_A0A6Q8PHF2-mappedCitation-36205702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36205702 |
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| http://purl.uniprot.org/uniprot/#_B7Z505-mappedCitation-36205702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36205702 |
| http://purl.uniprot.org/uniprot/#_B3KWB2-mappedCitation-36205702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36205702 |
| http://purl.uniprot.org/uniprot/#_B7Z5Z7-mappedCitation-36205702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36205702 |