| http://purl.uniprot.org/citations/36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36219563 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolyl hydroxylase domain protein 2 (PHD2)-catalyzed modification of hypoxia-inducible factor (HIF)-α is a key event in oxygen sensing. We previously showed that the zinc finger of PHD2 binds to a Pro-Xaa-Leu-Glu (PXLE) motif. Here, we show that the zinc finger binds to this motif in the ribosomal chaperone nascent polypeptide complex-α (NACA). This recruits PHD2 to the translation machinery to cotranslationally modify HIF-α. Importantly, this cotranslational modification is enhanced by a translational pause sequence in HIF-α. Mice with a knock-in Naca gene mutation that abolishes the PXLE motif display erythrocytosis, a reflection of HIF pathway dysregulation. In addition, human erythrocytosis-associated mutations in the zinc finger of PHD2 ablate interaction with NACA. Tibetans, who have adapted to the hypoxia of high altitude, harbor a PHD2 variant that we previously showed displays a defect in zinc finger binding to p23, a PXLE-containing HSP90 cochaperone. We show here that Tibetan PHD2 maintains interaction with NACA, thereby showing differential interactions with PXLE-containing proteins and providing an explanation for why Tibetans are not predisposed to erythrocytosis."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2022112059"xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/author | "Lee F.S."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/author | "Peng K."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/author | "Palmer B.E."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/pages | "e112059"xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/title | "The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-alpha."xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/36219563 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36219563 |
| http://purl.uniprot.org/citations/36219563 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36219563 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_E9PAV3-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_P70670-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_B4DDI8-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_A6XP74-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_I6QYW0-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_Q13765-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_Q60817-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_Q3UCW2-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |
| http://purl.uniprot.org/uniprot/#_Q3UK68-mappedCitation-36219563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36219563 |