| http://purl.uniprot.org/citations/36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36220081 | http://www.w3.org/2000/01/rdf-schema#comment | "Digit determination in limb buds is driven by a posteriorizing Sonic hedgehog (Shh) protein gradient; however, the mechanism regulating this is unclear. Here, we propose a diffusion-and-trapping hypothesis for Shh gradient formation based on data from the preaxial polydactyly phenotype of KIF3B motor hypomorphic mice. In the limb buds of these mice, a distal-to-proximal gradient of fibroblast growth factor (FGF) and phosphatidylinositol 3-kinase (PI3K) signaling and a posterior-to-anterior gradient of Shh were disorganized. This phenotype was reproduced by transplanting FGF8b-soaked beads. At the subcellular level, KIF3B transported the phosphatase and tensin homolog (PTEN)-like phosphatase Talpid3 to terminate PI3K signaling. High and low PI3K signaling strengths differentially sorted endocytosed Shh toward exosome-like particles and cytonemal punctata, respectively. These results indicate that the Shh-containing particles undergo either the diffusional movement in the periphery or cytonemal trapping in the center and form a spatial gradient along the periphery of developing limb buds."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2022.09.007"xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/author | "Hirokawa N."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/author | "Takeda S."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/pages | "2273-2289.e11"xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/title | "KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice."xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/36220081 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36220081 |
| http://purl.uniprot.org/citations/36220081 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36220081 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_D3YYP9-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_D4Q8H8-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_D4Q8I4-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |
| http://purl.uniprot.org/uniprot/#_E9Q0E2-mappedCitation-36220081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36220081 |