| http://purl.uniprot.org/citations/36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36226701 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms can generally be divided into two nutritional groups: generalists that consume various types of food and specialists that consume specific types of food. However, it remains unclear how specialists adapt to only limited nutritional conditions in nature. In this study, we addressed this question by focusing on Drosophila fruit flies. The generalist Drosophila melanogaster can consume a wide variety of foods that contain high glucose levels. In contrast, the specialist Drosophila sechellia consumes only the Indian mulberry, known as noni (Morinda citrifolia), which contains relatively little glucose. We showed that the lifespan of D. sechellia was significantly shortened under a high-glucose diet, but this effect was not observed for D. melanogaster. In D. sechellia, a high-glucose diet induced disorganization of the gut epithelia and visceral muscles, which was associated with abnormal digestion and constipation. RNA-sequencing analysis revealed that many immune-responsive genes were suppressed in the gut of D. sechellia fed a high-glucose diet compared with those fed a control diet. Consistent with this difference in the expression of immune-responsive genes, high glucose-induced phenotypes were restored by the addition of tetracycline or scopoletin, a major nutritional component of noni, each of which suppresses gut bacterial growth. We propose that, in D. sechellia, a high-glucose diet impairs gut immune function, which leads to a change in gut microbiota, disorganization of the gut epithelial structure and a shortened lifespan."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.org/dc/terms/identifier | "doi:10.1242/jeb.244423"xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Izumi Y."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Niwa R."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Qian Q."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Hattori Y."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Kamiyama T."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Degawa Y."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/author | "Yoshihashi Y."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/name | "J Exp Biol"xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/pages | "jeb244423"xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/title | "Shortened lifespan induced by a high-glucose diet is associated with intestinal immune dysfunction in Drosophila sechellia."xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://purl.uniprot.org/core/volume | "225"xsd:string |
| http://purl.uniprot.org/citations/36226701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36226701 |
| http://purl.uniprot.org/citations/36226701 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36226701 |
| http://purl.uniprot.org/uniprot/#_E1JH67-mappedCitation-36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36226701 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7Q5-mappedCitation-36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36226701 |
| http://purl.uniprot.org/uniprot/#_A1Z8G7-mappedCitation-36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36226701 |
| http://purl.uniprot.org/uniprot/#_A1ZB62-mappedCitation-36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36226701 |
| http://purl.uniprot.org/uniprot/#_O97355-mappedCitation-36226701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36226701 |