| http://purl.uniprot.org/citations/36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36230906 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional coactivator PGC-1α is a main regulator of cardiac energy metabolism. In addition to canonical PGC-1α1, other PGC-1α isoforms have been found to exert specific biological functions in a variety of tissues. We investigated the expression patterns and the biological effects of the non-canonical isoforms in the heart. We used RNA sequencing data to identify the expression patterns of PGC-1α isoforms in the heart. To evaluate the biological effects of the alternative isoform expression, we generated a transgenic mouse with cardiac-specific overexpression of PGC-1α4 and analysed the cardiac phenotype with a wide spectrum of physiological and biophysical tools. Our results show that non-canonical isoforms are expressed in the heart, and that the main variant PGC-1α4 is induced by β-adrenergic signalling in adult cardiomyocytes. Cardiomyocyte specific PGC-1α4 overexpression in mice relieves the RE1-Silencing Transcription factor (REST)-mediated suppression of neuronal genes during foetal heart development. The resulting de-repression of REST target genes induces a cardiac phenotype with increased cellular energy consumption, resulting in postnatal dilated cardiomyopathy. These results propose a new concept for actions of the PGC-1α protein family where activation of the Pgc-1α gene, through its isoforms, induces a phenotype with concurrent supply and demand for cellular energy. These data highlight the biological roles of the different PGC-1α isoforms, which should be considered when future therapies are developed."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells11192944"xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Naumenko N."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Ruas J.L."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Estall J.L."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Tavi P."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Shakirzyanova A."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Tuomainen T."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Sczelecki S."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/author | "Mutikainen M."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/pages | "2944"xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/title | "PGC-1alpha4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/36230906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36230906 |
| http://purl.uniprot.org/citations/36230906 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36230906 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGX4-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF8-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP88-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_D3YYN7-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |
| http://purl.uniprot.org/uniprot/#_D3Z2J0-mappedCitation-36230906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36230906 |