| http://purl.uniprot.org/citations/36240759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36240759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36240759 | http://www.w3.org/2000/01/rdf-schema#comment | "Microbiome dysbiosis is a feature of diabetes, but how microbial products influence insulin production is poorly understood. We report the mechanism of BefA, a microbiome-derived protein that increases proliferation of insulin-producing β cells during development in gnotobiotic zebrafish and mice. BefA disseminates systemically by multiple anatomic routes to act directly on pancreatic islets. We detail BefA's atomic structure, containing a lipid-binding SYLF domain, and demonstrate that it permeabilizes synthetic liposomes and bacterial membranes. A BefA mutant impaired in membrane disruption fails to expand β cells, whereas the pore-forming host defense protein, Reg3, stimulates β cell proliferation. Our work demonstrates that membrane permeabilization by microbiome-derived and host defense proteins is necessary and sufficient for β cell expansion during pancreas development, potentially connecting microbiome composition with diabetes risk."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2022.09.001"xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2022.09.001"xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Remington S.J."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Remington S.J."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Guillemin K."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Guillemin K."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Bell R."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Bell R."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Derrick D."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Derrick D."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Hill J.H."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Hill J.H."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Jahl P."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Jahl P."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Kallio K."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Kallio K."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Massaquoi M.S."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Massaquoi M.S."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Murtaugh L.C."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Murtaugh L.C."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Parthasarathy R."xsd:string |
| http://purl.uniprot.org/citations/36240759 | http://purl.uniprot.org/core/author | "Parthasarathy R."xsd:string |