| http://purl.uniprot.org/citations/36241425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36241425 | http://www.w3.org/2000/01/rdf-schema#comment | "New therapeutic targets are a valuable resource for treatment of SARS-CoV-2 viral infection. Genome-wide association studies have identified risk loci associated with COVID-19, but many loci are associated with comorbidities and are not specific to host-virus interactions. Here, we identify and experimentally validate a link between reduced expression of EXOSC2 and reduced SARS-CoV-2 replication. EXOSC2 was one of the 332 host proteins examined, all of which interact directly with SARS-CoV-2 proteins. Aggregating COVID-19 genome-wide association studies statistics for gene-specific eQTLs revealed an association between increased expression of EXOSC2 and higher risk of clinical COVID-19. EXOSC2 interacts with Nsp8 which forms part of the viral RNA polymerase. EXOSC2 is a component of the RNA exosome, and here, LC-MS/MS analysis of protein pulldowns demonstrated interaction between the SARS-CoV-2 RNA polymerase and most of the human RNA exosome components. CRISPR/Cas9 introduction of nonsense mutations within EXOSC2 in Calu-3 cells reduced EXOSC2 protein expression and impeded SARS-CoV-2 replication without impacting cellular viability. Targeted depletion of EXOSC2 may be a safe and effective strategy to protect against clinical COVID-19."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.202201449"xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Franklin J."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Gordon D."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Collins M.O."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Shaw P.J."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Krogan N."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Snyder M.P."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Hautbergue G."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Ferraiuolo L."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Rehwinkel J."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Harvey C."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Moll T."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Cooper-Knock J."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Castelli L."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Odon V."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Marshall J.N."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Azzouz M."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Peden A."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Dos Santos Souza C."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/author | "Graves E."xsd:string |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36241425 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |