| http://purl.uniprot.org/citations/36243815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36243815 | http://www.w3.org/2000/01/rdf-schema#comment | "In cultured cells, SARS-CoV-2 infects cells via multiple pathways using different host proteases. Recent studies have shown that the furin and TMPRSS2 (furin/TMPRSS2)-dependent pathway plays a minor role in infection of the Omicron variant. Here, we confirm that Omicron uses the furin/TMPRSS2-dependent pathway inefficiently and enters cells mainly using the cathepsin-dependent endocytosis pathway in TMPRSS2-expressing VeroE6/TMPRSS2 and Calu-3 cells. This is the case despite efficient cleavage of the spike protein of Omicron. However, in the airways of TMPRSS2-knockout mice, Omicron infection is significantly reduced. We furthermore show that propagation of the mouse-adapted SARS-CoV-2 QHmusX strain and human clinical isolates of Beta and Gamma is reduced in TMPRSS2-knockout mice. Therefore, the Omicron variant isn't an exception in using TMPRSS2 in vivo, and analysis with TMPRSS2-knockout mice is important when evaluating SARS-CoV-2 variants. In conclusion, this study shows that TMPRSS2 is critically important for SARS-CoV-2 infection of murine airways, including the Omicron variant."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-33911-8"xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Maeda K."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Takeda M."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Kawase M."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Tomita Y."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Matsuyama S."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Fukushi S."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Nagata N."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Tahara M."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Kakizaki M."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Shirato K."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Asanuma H."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Okura T."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Takayama I."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Iwata-Yoshikawa N."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/author | "Shiwa-Sudo N."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/pages | "6100"xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/title | "Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways."xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36243815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36243815 |