| http://purl.uniprot.org/citations/36245920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36245920 | http://www.w3.org/2000/01/rdf-schema#comment | "The excitatory action of gamma-aminobutyric-acid (GABA) in the median-eminence (ME) led to the steady-state release of corticotropin-releasing hormone (CRH) from CRH axon terminals, which modulates the hypothalamic-pituitary-adrenal (HPA) axis. However, in ME, the source of excitatory GABAergic input is unknown. We examined agouti-related peptide (AgRP) expressing neurons in the arcuate nucleus as a possible source for excitatory GABAergic input. Here, we show that a subpopulation of activated AgRP neurons directly project to the CRH axon terminals in ME elevates serum corticosterone levels in 60% food-restricted mice. This increase in serum corticosterone is not dependent on activation of CRH neuronal soma in the paraventricular nucleus. Furthermore, conditional deletion of Na+-K+-2Cl- cotransporter-1 (NKCC1), which promotes depolarizing GABA action, from the CRH axon terminals results in significantly lower corticosterone levels in response to food restriction. These findings highlight the important role of a subset of AgRP neurons in HPA axis modulation via NKCC1-dependent GABAergic excitation in ME."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnmol.2022.990803"xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Ishibashi M."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Fukuda A."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Sinha A.S."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/author | "Yesmin R."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/name | "Front Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/pages | "990803"xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/title | "A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction."xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/36245920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36245920 |
| http://purl.uniprot.org/citations/36245920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36245920 |
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