| http://purl.uniprot.org/citations/36253358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36253358 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal fibrosis is a common pathological feature and outcome of almost all chronic kidney diseases, and it is characterized by metabolic reprogramming toward aerobic glycolysis. Mesenchymal stem cell-derived exosomes (MSC-Exos) have been proposed as a promising therapeutic approach for renal fibrosis. In this study, we investigated the effect of MSC-Exos on glycolysis and the underlying mechanisms. We demonstrated that MSC-Exos significantly ameliorated unilateral ureter obstruction (UUO)-induced renal fibrosis by inhibiting glycolysis in tubular epithelial cells (TECs). miRNA sequencing showed that miR-21a-5p was highly enriched in MSC-Exos. Mechanistically, miR-21a-5p repressed the expression of phosphofructokinase muscle isoform (PFKM), a rate-limiting enzyme of glycolysis, thereby attenuating glycolysis in TECs. Additionally, knockdown of miR-21a-5p abolished the renoprotective effect of MSC-Exos. These findings revealed a novel role for MSC-Exos in the suppression of glycolysis, providing a new insight into the treatment of renal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-022-05305-7"xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Jia Y."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Rong R."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/author | "Cheuk Y.C."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/pages | "876"xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/title | "Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM."xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36253358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36253358 |
| http://purl.uniprot.org/citations/36253358 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36253358 |
| http://purl.uniprot.org/uniprot/#_A0A024R0Y5-mappedCitation-36253358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36253358 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y891-mappedCitation-36253358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36253358 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4A1-mappedCitation-36253358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36253358 |