| http://purl.uniprot.org/citations/36261006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36261006 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-27 (IL-27) uniquely assembles p28 and EBI3 subunits to a heterodimeric cytokine that signals via IL-27Rα and gp130. To provide the structural framework for receptor activation by IL-27 and its emerging therapeutic targeting, we report here crystal structures of mouse IL-27 in complex with IL-27Rα and of human IL-27 in complex with SRF388, a monoclonal antibody undergoing clinical trials with oncology indications. One face of the helical p28 subunit interacts with EBI3, while the opposite face nestles into the interdomain elbow of IL-27Rα to juxtapose IL-27Rα to EBI3. This orients IL-27Rα for paired signaling with gp130, which only uses its immunoglobulin domain to bind to IL-27. Such a signaling complex is distinct from those mediated by IL-12 and IL-23. The SRF388 binding epitope on IL-27 overlaps with the IL-27Rα interaction site explaining its potent antagonistic properties. Collectively, our findings will facilitate the mechanistic interrogation, engineering, and therapeutic targeting of IL-27."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.111490"xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Hua J."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Murphy C."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Hill J.A."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Welin M."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Savvides S.N."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Merceron R."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Hunter C.A."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Bloch Y."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Provost M."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Logan D.T."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Strand J."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Skladanowska K."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Aldridge D."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "White K.F."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/author | "Soete A."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/pages | "111490"xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/title | "Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27."xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/36261006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36261006 |