| http://purl.uniprot.org/citations/36266304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36266304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36266304 | http://www.w3.org/2000/01/rdf-schema#comment | "The aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) family of transcription factors, plays important roles in regulating xenobiotic metabolism, cellular differentiation, stem cell maintenance, as well as immunity. More recently, AHR has gained significant interest as a drug target for the development of novel cancer immunotherapy drugs. Detailed understanding of AHR-ligand binding has been hampered for decades by the lack of a three-dimensional structure of the AHR PAS-B domain. Here, we present multiple crystal structures of the Drosophila AHR PAS-B domain, including its apo, ligand-bound, and AHR nuclear translocator (ARNT) PAS-B-bound forms. Together with biochemical and cellular assays, our data reveal structural features of the AHR PAS-B domain, provide insights into the mechanism of AHR ligand binding, and provide the structural basis for the future development of AHR-targeted therapeutics."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-33858-w"xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-33858-w"xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Qu L."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Qu L."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36266304 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |