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http://purl.uniprot.org/citations/36272177http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36272177http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To assess HOXC9 expression in non-small cell lung cancer (NSCLC) using bioinformatics analysis with experimental validation and to investigate its role and potential mechanisms in NSCLC.

Methods

Public databases were explored to investigate the gene expression, clinical outcomes, immune infiltration, and potential molecular mechanisms of HOXC9 in NSCLC. Next, HOXC9 expression levels in NSCLC were verified by RT-PCR and nucleic acid electrophoresis. In vitro experiments were performed to assess the effects of HOXC9 on proliferation, migration, and invasion of NSCLC cells.

Results

HOXC9 expression was increased in NSCLC and correlated with poor prognosis in lung adenocarcinoma. In addition, HOXC9 expression levels were significantly correlated with immune cell infiltration of tumors and biomarkers of immune cells. Overexpression of HOXC9 promoted NSCLC cell proliferation, migration, and invasion in vitro. Finally, the circCENPF/hsa-miR-184 axis was identified as the most promising upstream regulatory pathway of HOXC9 in lung adenocarcinoma.

Conclusion

HOXC9 expression may reflect the prognosis and immune microenvironment infiltration in NSCLC, emerging as a potential oncogene and a new target for immunotherapy."xsd:string
http://purl.uniprot.org/citations/36272177http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2022.10.043"xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/author"Jing L."xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/name"Biochem Biophys Res Commun"xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/pages"128-135"xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/title"circRNA-mediated upregulation of HOXC9 is correlated with poor outcome and immune microenvironment infiltrates in LUAD."xsd:string
http://purl.uniprot.org/citations/36272177http://purl.uniprot.org/core/volume"635"xsd:string
http://purl.uniprot.org/citations/36272177http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36272177
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http://purl.uniprot.org/uniprot/#_O15222-mappedCitation-36272177http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36272177
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