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http://purl.uniprot.org/citations/36275878http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36275878http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP265-273, and its IBV and ICV homologues, presented by HLA-A*03:01 molecule expressed in ~ 4% of the global population (~ 300 million people).

Methods

We assessed the magnitude (tetramer staining) and quality of the CD8+ T cell response (intracellular cytokine staining) towards NP265-IAV and described the T cell receptor (TCR) repertoire used to recognise this immunodominant epitope. We next assessed the immunogenicity of NP265-IAV homologue peptides from IBV and ICV and the ability of CD8+ T cells to cross-react towards these homologous peptides. Furthermore, we determined the structures of NP265-IAV and NP323-IBV peptides in complex with HLA-A*03:01 by X-ray crystallography.

Results

Our study provides a detailed characterisation of the CD8+ T cell response towards NP265-IAV and its IBV and ICV homologues. The data revealed a diverse repertoire for NP265-IAV that is associated with superior anti-viral protection. Evidence of cross-reactivity between the three different influenza virus strain-derived epitopes was observed, indicating the discovery of a potential vaccination target that is broad enough to cover all three influenza strains.

Conclusion

We show that while there is a potential to cross-protect against distinct influenza virus lineages, the T cell response was stronger against the IAV peptide than IBV or ICV, which is an important consideration when choosing targets for future vaccine design."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.org/dc/terms/identifier"doi:10.1002/cti2.1422"xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Gras S."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Nguyen A.T."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Mifsud N.A."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Jayasinghe D."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Grant E.J."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Szeto C."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Sloane H."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Chatzileontiadou D.S."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/author"Lau H.M.P."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/name"Clin Transl Immunology"xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/pages"e1422"xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/title"Homologous peptides derived from influenza A, B and C viruses induce variable CD8+ T cell responses with cross-reactive potential."xsd:string
http://purl.uniprot.org/citations/36275878http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/36275878http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36275878
http://purl.uniprot.org/citations/36275878http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36275878
http://purl.uniprot.org/uniprot/#_P13884-mappedCitation-36275878http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36275878
http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-36275878http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36275878
http://purl.uniprot.org/uniprot/#_P04439-mappedCitation-36275878http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36275878
http://purl.uniprot.org/uniprot/P13884http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36275878
http://purl.uniprot.org/uniprot/P04439http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36275878
http://purl.uniprot.org/uniprot/P61769http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36275878
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