| http://purl.uniprot.org/citations/36278424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36278424 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by impaired lymphocyte cytotoxicity. First-line therapeutic regimens directed against activated immune cells or secreted cytokines show limited efficacy since they do not target the underlying immunological problem: defective lymphocyte cytotoxicity causing prolonged immune stimulation. A potential rescue strategy would be the adoptive transfer of ex vivo gene-corrected autologous T cells. However, transfusion of cytotoxicity-competent T cells under conditions of hyperinflammation may cause more harm than benefit. As a proof-of-concept for adoptive T cell therapy (ATCT) under hyperinflammatory conditions, we transferred syngeneic, cytotoxicity-competent T cells into mice with virally triggered active primary HLH. ATCT with functional syngeneic trigger-specific T cells cured Jinx mice from active HLH without life-threatening side effects and protected Perforin-deficient mice from lethal HLH progression by reconstituting cytotoxicity. Cured mice were protected long-term from HLH relapses. A threshold frequency of transferred T cells with functional differentiation was identified as a predictive biomarker for long-term survival. This study is the first proof-of-concept for ATCT in active HLH."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.org/dc/terms/identifier | "doi:10.15252/emmm.202216085"xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Cathomen T."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Ehl S."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Schell C."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Ammann S."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Aichele P."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Kogl T."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Weissert K."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/author | "Dettmer-Monaco V."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/name | "EMBO Mol Med"xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/pages | "e16085"xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/title | "Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)."xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/36278424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36278424 |
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