| http://purl.uniprot.org/citations/36281761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36281761 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the total synthesis of the macrodiolide C(13)/C(13')-bis(desmethyl)disorazole Z through double inter-/intramolecular Stille cross-coupling of a monomeric vinyl stannane/vinyl iodide precursor to form the macrocycle. The key step in the synthesis of this precursor was a stereoselective aldol reaction of a formal Evans acetate aldol product with crotonaldehyde. As demonstrated by X-ray crystallography, the binding mode of C(13)/C(13')-bis(desmethyl)disorazole Z to tubulin is virtually identical with that of the natural product disorazole Z. Likewise, C(13)/C(13')-bis(desmethyl)disorazole Z inhibits tubulin assembly with at least the same potency as disorazole Z and it appears to be a more potent cell growth inhibitor."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.org/dc/terms/identifier | "doi:10.1002/anie.202212190"xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/author | "Oliva M.A."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/author | "Altmann K.H."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/author | "Diaz J.F."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/author | "Lucena-Agell D."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/author | "Bold C.P."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/name | "Angew Chem Int Ed Engl"xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/pages | "e202212190"xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/title | "Synthesis and Biological Evaluation of C(13)/C(13')-Bis(desmethyl)disorazole Z."xsd:string |
| http://purl.uniprot.org/citations/36281761 | http://purl.uniprot.org/core/volume | "62"xsd:string |
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