| http://purl.uniprot.org/citations/36291187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36291187 | http://www.w3.org/2000/01/rdf-schema#comment | "Mature astrocytes are characterized by a K+ conductance (passive conductance) that changes with a constant slope with voltage, which is involved in K+ homeostasis in the brain. Recently, we reported that the tandem of pore domains in a weak inward rectifying K+ channel (TWIK1 or KCNK1) and TWIK-related K+ channel 1 (TREK1 or KCNK2) form heterodimeric channels that mediate passive conductance in astrocytes. However, little is known about the binding proteins that regulate the function of the TWIK1/TREK1 heterodimeric channels. Here, we found that β-coat protein (COP) regulated the surface expression and activity of the TWIK1/TREK1 heterodimeric channels in astrocytes. β-COP binds directly to TREK1 but not TWIK1 in a heterologous expression system. However, β-COP also interacts with the TWIK1/TREK1 heterodimeric channel in a TREK1 dependent manner and enhances the surface expression of the heterodimeric channel in astrocytes. Consequently, it regulates TWIK1/TREK1 heterodimeric channel-mediated passive conductance in astrocytes in the mouse brain. Taken together, these results suggest that β-COP is a potential regulator of astrocytic passive conductance in the brain."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells11203322"xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Kwon S.H."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Kim S.S."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Park J.Y."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Bae Y."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Kwon O."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Hwang E.M."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/author | "Seo J.B."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/pages | "3322"xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/title | "beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes."xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/36291187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36291187 |
| http://purl.uniprot.org/citations/36291187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36291187 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RMH2-mappedCitation-36291187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/#_P97438-mappedCitation-36291187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/#_O08581-mappedCitation-36291187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/#_Q6P6P9-mappedCitation-36291187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/O08581 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/P97438 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/Q6P6P9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36291187 |
| http://purl.uniprot.org/uniprot/A0A1D5RMH2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36291187 |