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http://purl.uniprot.org/citations/36301759http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36301759http://www.w3.org/2000/01/rdf-schema#comment"

Background

Squamous cell carcinoma antigen (SCCA) was originally isolated as tumour-specific antigens in uterine cervix carcinoma. These comprise two similar proteins, SCCA1 and SCCA2, and both are induced by type 2 cytokines such as interleukin (IL)-4 and IL-13. The involvement of these antigens in atopic dermatitis has been reported, however, the role in mycosis fungoides (MF) and Sézary syndrome (SS), which are also linked with type 2 cytokines, remains to be seen.

Objectives

This study investigated a possible association between SCCA1/2 and MF/SS.

Materials & methods

We compared serum levels of SCCA1/2 between MF/SS patients and healthy controls. We also examined the correlation between serum SCCA1/2 levels in MF/SS patients and clinical disease markers. The expression of SCCA1/2 in skin samples was examined by immunohistochemistry.

Results

The serum levels of SCCA1/2 in MF/SS patients were significantly higher than those in normal controls and correlated with clinical disease markers. Immunohistochemical staining showed upregulated expression of SCCA1/2 in MF/SS lesional skin.

Conclusion

Enhanced SCCA1/2 expression may contribute to the progression of MF/SS. Measurement of serum SCCA1/2 levels may become a useful tool to evaluate the progression or therapeutic effects of MF/SS."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.org/dc/terms/identifier"doi:10.1684/ejd.2022.4305"xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Sato S."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Mizuno Y."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Oka K."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Oka T."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Suga H."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Omori I."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Miyagawa T."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Sugaya M."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Hisamoto T."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Miyagaki T."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Kamijo H."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Takahashi-Shishido N."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/author"Boki H."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/name"Eur J Dermatol"xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/pages"464-470"xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/title"Increased expression of squamous cell carcinoma antigen 1 and 2 in mycosis fungoides and Sezary syndrome."xsd:string
http://purl.uniprot.org/citations/36301759http://purl.uniprot.org/core/volume"32"xsd:string
http://purl.uniprot.org/citations/36301759http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36301759
http://purl.uniprot.org/citations/36301759http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36301759
http://purl.uniprot.org/uniprot/#_O95740-mappedCitation-36301759http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36301759
http://purl.uniprot.org/uniprot/#_P48594-mappedCitation-36301759http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36301759
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